Wisnovsky Lab Publications

Vignesh Krishnamoorthy, John Daly, Jimmy Kim, Lidia Piatnitca, Katie Yuen, Bhoj Kumar, Mehrnoush Taherzadeh Ghahfarrokhi, Tom Q.T. Bui, Parastoo Azadi, Ly P Vu, Simon Wisnovsky*. The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9. Leukemia In Press (2024)

Natalie Stewart, John Daly, Olivia Drummond-Guy, Vignesh Krishnamoorthy, Jessica C. Stark, Nicholas M. Riley, Karla C. Williams, Carolyn R. Bertozzi, Simon P. Wisnovsky*. The glyco-immune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. Journal of Biological Chemistry. 300(2):105579 (2023).

Vignesh Krishnamoorthy, John Daly, Simon Wisnovsky. Identifying Genetic Regulators of Protein-Glycan Interactions with Genome-Wide CRISPR Screening. Current Protocols in Chemical Biology e646 (2023).

Natalie Stewart, Simon Wisnovsky. Bridging Glycomics and Genomics: New Uses of Functional Genetics in the Study of Cellular Glycosylation. Frontiers in Molecular Biosciences 9, 934584 (2022).

Simon Wisnovsky, Carolyn R. Bertozzi. Reading the Glyco-Code: Cell-Based Approaches to Studying Protein-Carbohydrate Interactions. Current Opinion in Structural Biology 75, 102395 (2022).

Postdoctoral Publications

( * indicates co-authorship)

Green Ahn, Roarke Kamber, Simon Wisnovsky, Nicholas M. Riley, Michael C. Bassik, Steven M. Banik, Carolyn R. Bertozzi. Cellular determinants of targeted membrane protein degradation by lysosome targeting chimeras. Science 382, 6668 (2023)

Kayvon Pedram*, D. Judy Shon*, Gabby S. Tender*, Angel Kuo, Simon Wisnovsky, Giovanni C. Forcina, Stacy A. Malaker, Davey Huang, Carolyn R. Bertozzi. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nature Biotechnology In Press (2023).

Simon Wisnovsky, Leonhard Moeckl, Stacy A. Malaker, Kayvon Pedram, Nick Riley, Gaelen Hess, Melissa A. Gray, Benjamin A.H. Smith, Michael Bassik, W.E. Moerner, Carolyn R. Bertozzi. Genome-Wide CRISPR Screens Reveal a Specific Ligand for the Glycan-Binding Immune Checkpoint Receptor Siglec-7. PNAS 118, e2015024118 (2021).

Marjoke F. Debets*, Omur Y. Tastan*, Simon Wisnovsky, Stacy A. Malaker, Nikolaos Angelis, Leonhard K. R. Moeckl, Junwon Choi, Helen Flynn, Lauren J. S. Wagner, Ganka Bineva Todd, Holly L. Douglas, Aristotelis Antononopoulos, Anna Cioce, William J. Browne, Zhen Li, David C. Briggs, Gaelen T. Hess, Anthony J. Agbay, Chloe Roustan, Stuart Haslam, Ambrosius P. Snijders, Michael C. Bassik, William E. Moerner, Vivian S. W. Li, Carolyn R. Bertozzi, Benjamin Schumann. Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS 117, 25293-25301 (2020).

Benjamin Schumann, Stacy A. Malaker, Simon Wisnovsky, Marjoke F. Debets, Anthony J. Agbay, Daniel Fernandez, Lauren J. S. Wagner, Liang Lin, Zhen Li, Junwon Choi, Douglas M. Fox, Jessie M. Peh, Melissa A. Gray, Kayvon Pedram, Jennifer J. Kohler, Milan Mrksich, Carolyn R. Bertozzi. Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells. Molecular Cell 78, 824-834 (2020).

Steven M. Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, Nicholas M. Riley, Carolyn R. Bertozzi. Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins. Nature 584, 291-297 (2020).

PhD Publications

Simon Wisnovsky, Tanja Sack, David Pagliarini, Rebecca Laposa, Shana O. Kelley. DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA. ACS Chemical Biology 13, 900-908 (2018).

Simon Wisnovsky, Sae Rin Jean, Sanduni Liyanage, Aaron Schimmer, Shana O. Kelley. Mitochondrial DNA Repair and Replication Proteins Revealed by Targeted Chemical Probes. Nature Chemical Biology 12, 567-573 (2016).

Simon Wisnovsky, Eric Lei, Sae Rin Jean, Shana O. Kelley. Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell. Cell Chemical Biology 23, 917-927 (2016).

Simon Wisnovsky*, Justin Wilson*, Robert Radford, Mark Pereira, Maria Chan, Rebecca Laposa, Stephen Lippard, Shana O. Kelley. Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent. Cell Chemical Biology 20, 1323-1328 (2013).

Roxana Alta, Hector Vitorino, Dibakar Goswami, Cleber Liria, Simon Wisnovsky, Shana O. Kelley, M. Teresa Machini, Bruno P. Esposito. Mitochondria-Penetrating Peptides Conjugated to Desferrioxamine as Chelators for Mitochondrial Labile Iron. PLoS One 12, e0171729 (2017).

Sae Rin Jean, Marya Ahmed, Eric K. Lei, Simon Wisnovsky, Shana O. Kelley. Peptide-mediated Delivery of Probes and Therapeutics to Mitochondria. Accounts of Chemical Research 49, 1893-1902 (2016).

Sae Rin Jean, David V. Tulumello, Simon Wisnovsky, Eric K. Lei, Mark P. Pereira, and Shana O. Kelley. Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery. ACS Chemical Biology 9, 323-333 (2014).

Rida Mourtada, Sonali Fonseca, Simon Wisnovsky, Mark Pereira, Xiaoming Wang Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin Smith, Michael Murphy, Aaron Schimmer, Shana O. Kelley. Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism. PLoS ONE. 9, e60253 (2013).

Glen Deleavey, Fillip Frank, Matthew Hassler, Simon Wisnovsky, Bhushan Nagar, Masad Damha. The 5′ Binding MID Domain of Human Argonaute2 Tolerates Chemically Modified Nucleotide Analogues. Nucleic Acid Therapeutics 23, 81-87 (2013).